CDKN2A/B rs4977756 and glioma risk: a meta-analysis
نویسندگان
چکیده
Background: Several studies were performed to investigate the association between CDKN2A/B rs4977756 polymorphism and the risk of glioma. However, the results were inconsistent. Thus, we performed this meta-analysis. Methods: Eleven studies including 12814 glioma patients and 21140 controls were included in the meta-analysis. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) was assessed. Results: CDKN2A/B rs4977756 polymorphism was significantly associated with an increased risk of glioma (OR=1.25; 95% CI, 1.211.30; P<0.00001). In the subgroup analysis by race, CDKN2A/B rs4977756 polymorphism was significantly associated with an increased risk of glioma in Caucasian (OR=1.27; 95% CI, 1.22-1.31; P<0.00001). However, no significant association between CDKN2A/B rs4977756 polymorphism and glioma risk was found in Asian (OR=1.05; 95% CI, 0.92-1.21; P=0.45). Conclusions: This meta-analysis suggested that DKN2A/B rs4977756 polymorphism may be a risk factor of glioma.
منابع مشابه
Two gene polymorphisms (rs4977756 and rs11515) in CDKN2A/B and glioma risk in South Indian population
Gliomas are most common neoplasms in the CNS with unknown aetiology. Gene polymorphisms have been studied in glioma to check its risk in different population. CDKN2A, commonly altered tumor suppressor gene polymorphisms were recently shown to be associated with glioma in Caucasians. Present study evaluated potential association between two SNPs in CDKN2A/B gene with glioma risk in South Indian ...
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